BioEsse® is a revolutionary skin care product based on the science of the human microbiome, our “invisible organ.” Our microbiome is made up of trillions of beneficial microbes inhabiting our bodies. They protect us from disease, environmental toxins and other dangers, produce vitamins and other nutrients and regulate our immune systems. Specially developed with this science in mind, BioEsse’s products were studied in a clinical setting with participants over a 30-day period to view its results on their skin.

What does BioEsse® do? Real-life results from real people.

Starting as early as 2 weeks, many participants in a 4 week BioEsse clinical trial had visibly improved skin, assessed by VISIA Facial Scanner.

More than half of the 21 participants, aged 22 – 69, had improved appearance in facial lines, wrinkles and skin pores, as well as smoother skin and more even complexions.

They experienced improvements up to:

  • 100% Better skin texture & smoothness
  • 94% Improved overall skin quality
  • 83% Less facial redness

Participants used the BioEsse® BioEssential Hydrating Cleanser and BioEsse® BioEssential Rejuvenating Facial Serum, twice a day.

BioEsse® is clinically proven to reduce the appearance of fine lines and blotchy patches and fight the appearance of aging.

Our Science & Clinical Results

Cosmetic Study Design:

A bio-identical probiotic-containing skin regimen (BioEsse® BioEssential Hydrating Cleanser, BioEsse® BioEssential Rejuvenating Facial Serum, both used 2x/day) was assessed in 21 participants (17 females, 4 males, ages 22-69).

Participants had multiple skin concerns (see below); 14 had moderate to advanced photo aging. VISIA Facial Scanner readings were performed at 0, 14 and 28 days, and analyzed for visible spots, pores, skin texture, wrinkles, redness, melanin and UV damage. Participant questionnaires were performed at 14, 28 and 60 days.

At 2 weeks, VISIA analysis showed approximately 75% of participants had visible skin improvement, with over 50% of participants improving in all parameters, including fine lines, wrinkles, hyperpigmentation, pore size and skin texture.

By 4 weeks, 100% of participants demonstrated visible improvements in skin appearance by VISIA facial analysis. VISIA at 4 weeks showed reduced appearance of fine lines and wrinkles of up to 76%, with less skin dryness and better skin texture of up to 37%.

All participants who self-reported skin redness improved by 2 weeks, with continued reductions in facial redness of up to 52% at 4 weeks, with a 4-week median improvement of 11%, documented by decreased erythema per VISIA. The facial products were well tolerated, including panelists with self-reported sensitive skin.

Study Results: 14 and 28 Day Improvement in Cosmetic Parameters vs Baseline

Individual improvement at 14 days
Wrinkles up to 60% improvement
Pores up to 25% improvement
Visible spots up to 15% improvement
UV Damage up to 15% improvement
Brown Spots up to 15% improvement
Redness up to 30% improvement
Skin Texture up to 35% improvement
Individual improvement at 28 days
Wrinkles up to 76% improvement
Pores up to 32% improvement
Visible Spots up to 50% improvement
UV Damage up to 31% improvement
Brown Spots up to 12% improvement
Redness up to 50% improvement
Skin Texture up to 37% improvement

User Survey Results

  • Anonymous Questionnaires at 2, 4 and 8 weeks showed a 92% product approval rating.
  • Skin quality and texture improved in 90-95% of users by 2 weeks.

4-week clinical study participant survey of BioEsse® system *:

  • 100%: better skin texture & smoothness
  • 94%: improved overall skin quality
  • 83%: less facial redness

In an 8-week clinical study with the BioEsse® system**:

  • 100%: more even-toned facial complexion
  • 93%: more luminous skin
  • 87%: anti-aging effects (younger appearance, firmer facial skin)

*4-week clinical study of 21 participants, 17 female, 4 male.
**8-week clinical study of 17 participants, 15 female, 2 male.

Study Participant Questionnaire revealed a 100% positive rating of the importance of a probiotic skin care ingredient as a deciding factor for future skin care product purchase

All subjects felt skin probiotic technology was a deciding factor for future skin-care purchase decisions. Questionnaire analysis showed a 100% end-trial personal conversion from non-consumers of probiotic skincare products, to future consumers of probiotic-containing skin care subjects.

This high rate of consciousness conversion of the skin care consumer initially naïve to the probiotic-for-the-skin concept to a skin care consumer actively seeking out and choosing probiotic skin care is an excellent predictor for repeat product purchase.

BioEsse® Skin Care System Clinical Participant Improvement

BioEsse Participant

Participant after 4 weeks of BioEsse® with 76% improvement in appearance of wrinkle depth and intensity

BioEsse Participant

Participant after 4 weeks of BioEsse: 62% decrease in eye area wrinkle appearance (marked in green); note also smoother appearance of skin overall)